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Image Search Results
Journal: bioRxiv
Article Title: Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease
doi: 10.1101/2025.01.29.635576
Figure Lengend Snippet: ( a ) Dose-dependent editing by wild-type and D220R NanoCas delivered as mRNA via nucleofection to human T cells (TRAC locus) and CD34+ HSPCs (BCL11A enhancer). ( b ) Experimental design for comparing NanoCas and SaCas9-mediated Pcsk9 editing via delivery of 2e13vg/kg of AAV8 via tail vein injection. ( c ) Pcsk9 editing efficiency two weeks post-treatment. ( c ) Corresponding serum PCSK9 protein levels.
Article Snippet:
Techniques: Injection